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In particular, back in 1996 Przedborski and colleagues indicated that GSH peroxidase activity is reduced in a specific brain region affected in ALS, the precentral gyrus, suggesting that the observed deficit could be involved in the oxidative damage observed in sporadic ALS [102]

Uncovering the metabolic roots of Huntingtons disease, this study reveals how early dopamine imbalances linked to GSTO2 may open new doors to preventive therapies for neurodegeneration

(5.4) Hypervitaminosis A: Patients with renal failure or liver disease may be at higher risk